NANoREG D4 17NANoREG D4 17 DR Development of PBPK models Acesse: https://www.rivm.nl/en/documenten/nanoreg-d4-17-dr-development-of-pbpk-models
NANoREG D4 18NANoREG D4.18 DR Overall evaluation of data, publication, and transfer to OECD sponsorship programme Acesse: https://www.rivm.nl/documenten/nanoreg-d418-dr-overall-evaluation-of-data-publication-and-transfer-to-oecd-sponsorship
NANoREG D5 01NANoREG D5 01 DR Report on identification and setting of categorization read across and extra intrapolation criteria Acesse: https://www.rivm.nl/en/documenten/nanoreg-d5-01-dr-report-on-identification-and-setting-of-categorization-read-across-and
NANoREG D5 02NANoREG D5 02 DR Report on the development of a solubility testing procedure Acesse: https://www.rivm.nl/en/documenten/nanoreg-d5-02-dr-report-on-development-of-solubility-testing-procedure
NANoREG D5 03NANoREG D5.03 DR In vitro screening methodology for absorption or crossing of other barriers Acesse: https://www.rivm.nl/en/documenten/nanoreg-d503-dr-in-vitro-screening-methodology-for-absorption-or-crossing-of-other SOPs available in deliverable: SOP 01 Protocol for organotypic cell culture modified for exposure to nanomaterials SOP 02 Caco-2 cell culture and differentiation SOP 03 Evaluation of NMs impact on Caco-2 cell barrier model
NANoREG D5 04NANoREG D5 04 DR In vitro screening methodology to evaluate toxicity by inhalation Acesse: https://www.rivm.nl/en/documenten/nanoreg-d5-04-dr-in-vitro-screening-methodology-to-evaluate-toxicity-by-inhalation
NANoREG D5 05NANoREG D5 05 DR Report on cell type and in vitro in vivo correlation studies for inhalation toxicity Acesse: https://www.rivm.nl/en/documenten/nanoreg-d5-05-dr-report-on-cell-type-and-in-vitro-in-vivo-correlation-studies-for
NANoREG D5 06NANoREG D5 06 DR Identification and optimization of the most suitable in vitro methodology Acesse: https://www.rivm.nl/en/documenten/nanoreg-d5-06-dr-identification-and-optimization-of-most-suitable-in-vitro-methodology SOPs available in deliverable: SOP 01 LAL Assay for Nanoparticles SOP 02 LDH assay SOP 03 Reaction Oxygen Species Detection SOP 04 Human Lung Cell transformation assay. Long term chronic experiment SOP 05 Apoptosis/Necrosis Analysis SOP 06 Production of pro-inflammatory cytokines
NANoREG D5 07NANoREG D5.07 SOP 01 SOP for Dispersion Acesse: https://www.rivm.nl/documenten/nanoreg-d507-sop-01-sop-for-dispersion
